After+the+the+Confederate+loss+at+Vicksburg,+the+Union+controlled+which+important+River?

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After the the Confederate loss at Vicksburg, the Union controlled which important River? The Mississippi River. May 1863 -- The Vicksburg Campaign. Union General Ulysses S. Grant won several victories around Vicksburg, Mississippi, the fortified city considered essential to the Union's plans to regain control of the Mississippi River. On May 22, Grant began a siege of the city. After six weeks, Confederate General John Pemberton surrendered, giving up the city and 30,000 men. The capture of Port Hudson, Louisiana, shortly thereafter placed the entire Mississippi River in Union hands. The Confederacy was split in two.